Dopaminergic Induced Changes in Mauthner-cell Excitability Disrupts Prepulse Inhibition
نویسندگان
چکیده
Dopaminergic induced changes in Mauthner-cell excitability disrupts prepulse inhibition 1 in the startle circuit of goldfish. 2 3 Violeta Medan and Thomas Preuss 4 5 Department of Psychology, Hunter College, City University of New York 6 695 Park Avenue, New York, NY 10065 7 8 Running head: dopaminergic disruption of prepulse inhibition 9 10 Corresponding author: Thomas Preuss, [email protected]. Department of Psychology, 11 Hunter College, City University of New York. 695 Park Avenue, New York, NY 10065 12 13 Articles in PresS. J Neurophysiol (September 28, 2011). doi:10.1152/jn.00644.2011
منابع مشابه
Dopaminergic-induced changes in Mauthner cell excitability disrupt prepulse inhibition in the startle circuit of goldfish.
Prepulse inhibition (PPI) is a widespread sensorimotor gating phenomenon characterized by a decrease in startle magnitude if a nonstartling stimulus is presented 20-1,000 ms before a startling stimulus. Dopaminergic agonists disrupt behavioral PPI in various animal models. This provides an important neuropharmacological link to schizophrenia patients that typically show PPI deficits at distinct...
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Predator pressure and olfactory cues (alarm substance) have been shown to modulate Mauthner cell (M-cell) initiated startle escape responses (C-starts) in teleost fish. The regulation of such adaptive responses to potential threats is thought to involve the release of steroid hormones such as cortisol. However, the mechanism by which cortisol may regulate M-cell excitability is not known. Here,...
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Prepulse inhibition (PPI) is typically associated with an attenuation of auditory startle behavior in mammals and is presumably mediated within the brainstem startle circuit. However, the inhibitory mechanisms underlying PPI are not yet clear. We addressed this question with complementary behavioral and in vivo electrophysiological experiments in the startle escape circuit of goldfish, the Maut...
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Excitability changes during collateral inhibition of the goldfish Mauthner cell (M cell) were measured directly by stimulating the cell with current pulses applied through an intracellular electrode. Excitability was suppressed during the extrinsic hyperpolarizing potential (EHP) as well as during the collateral IPSP. The inhibitory effect of the EHP was shown to be comparable in intensity to t...
متن کاملTITLE Behavioral and physiological characterization of sensorimotor gating in the goldfish startle response AUTHORS
Prepulse inhibition (PPI) is typically associated with an attenuation of auditory startle behavior in mammals and is presumably mediated within the brainstem startle circuit. However, the inhibitory mechanisms underlying PPI are not yet clear. We addressed this question in behavioral and complementary in vivo electrophysiological experiments in the startle escape circuit of goldfish, the Mauthn...
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